So, this post is about Sable, our 2-year old baby who is a 50 pound 3/4 pit bull, 1/4 lab mix. She is a real wiggle worm. I was looking for some advice and thought that with everyone’s experiences here, someone may have a recommendation or two.
Here’s the story:
When we first adopted her from an “accidental” backyard litter in Michigan, we noticed her hair was starting to fall out and her skin was irritated. We took her into our vet (actually our vet came to us as we had a mobile vet who showed up in a big motor home that’d been converted into a mobile vet clinic complete with microscope, x-ray machine, and most of the other stuff you’d find in a regular vet office) and the vet determined Sable had demodex mange based on the skin scraping she inspected under a microscope. She prescribed “off-the-label” use of ivermection and provided us with proper dosage information. For those of you who don’t know, ivermection is a cattle dewormer which is typically injected into the cattle. With dogs, it’s given orally at a dosage that’s gradually stepped up over time to ensure no neurological issues develop. It is worth mentioning here that ivermectin often causes issues with herding breeds due to the often present MDR1 (Multi Drug Resistant 1) gene which leads to normal dosages being toxic for the animal in question.
Back to the story… at the time she was diagnosed, she probably weighed 10 pounds or less. I don’t remember exactly how much she weighed, but it wasn’t much. Regardless, she tolerated the ivermectin without any issue and the symptoms of her demodex mange cleared up and all was well.
Fast forward to a couple of weeks ago. What appeared to us to be similar symptoms started showing up again. We called to make an appointment with our vet and learned that our usual practitioner was out of town at a conference for the next several days so I asked to make an appointment with someone else as Sable had become VERY itchy – to the point she was chewing herself raw – hair off, scabs forming, bloody paws, etc. They set us up to see another provider shortly thereafter. We had already started her on Benadryl in hopes of alleviating the incessant itching.
The new provider did a skin scraping and said she didn’t see any demodex mites on Sable and suggested antibiotics for a few days and ivermectin at that point if it didn’t clear up. We were able to rule out sarcoptic mange, scabies, and fleas since none of our other dogs are itchy, nor are we. I asked her if there would be any disadvantage to beginning the ivermectin right away since we all agreed that the symptoms did present as demodex mange, even though none were seen on the scraping. She said there weren’t any concerns and provided us with a chart that showed how many cc’s to give orally per 10 pounds of body weight. Since Sable weighs 52 pounds, we were told to give her 5x the amount shown on the chart. We talked about whether or not we dilute the ivermectin in something else (cherry syrup, vegetable oil, etc.) and we told her we hadn’t in the past, we just squirted it on her food and she gobbled it down. The vet said that’s very uncommon since the ivermectin is known to have an unpleasant flavor and she commented on what a good girl Sable is to eat it without giving us any trouble. She suggested continuing the Benadryl at this point. Our initial appointment was last Monday, July 28th. We began the antibiotics that night, continued with the Benadryl and started the first step of the ivermectin treatment the next day – Tuesday, July 29th.
We continued on the same course of treatment for the coming days until Sunday, August 3rd. That morning, we woke-up, fed the dogs and took off to run errands for a couple of hours. When we returned, we noticed Sable was acting very unusually – super wobbly, HUGE pupils and doing weird stuff like running into walls, pushing her nose up against immobile objects and almost seeming blind. She wasn’t at all her usual wiggly self. I called our regular clinic (who has Sunday hours) and they didn’t have any availability so we rushed to the emergency vet. Upon discussion with them, they determined it was ivermectin toxicity and advised the best course of action would be to empty her stomach using activated charcoal and pump IV fluids for the next 12+ hours. They admitted her and we went home sad and concerned. The next morning they called and said we could come pick her up and that they trusted she was stable. They advised us her liver enzymes were out of whack and that she needed to take a liver supplement
We picked her up, brought her home and she was still almost in a comatose state – very non-responsive to our voices and even to poking at her or gently shaking her about. I called the emergency vet back and talked about her symptoms. They advised we could bring her back if we were genuinely concerned. At this point I started scouring the internet where I learned a few very important things. Thankfully she was interested when there was food around, when she’d fallen into these deep sleeps, she would eventually wake her up with a medium amount of effort on our part, she was breathing without any noticeable issues and her body temperature seemed normal. These are all good signs when it comes to ivermectin toxicity.
#1 – Sable had been given several doses of ivermectin that were WAY TOO HIGH for her body size. Upon further investigation, I was able to determine the dosage chart we were given from the vet assumed we were diluting the ivermection at a ratio of approximately 1:10. Remember I said we were supposed to step-up the dosage over the course of time to get to the full dose after more than a week? Well, on the first day, she received a dosage that was almost double the full recommended dosage. Meaning, the full dosage she should have received after 10+ days is 0.7 cc’s, but she received 1.25 cc’s on the first day, more the second and third day, and by the fourth and fifth day, she was receiving 3.5 cc’s once per day. Again, the MAX dose for a 50 pound dog is 0.7 cc’s. That’s obviously an unacceptably HUGE difference.
#2 – Ivermectin has a half-life of 48-72 hours.
#3 – The symptoms of ivermectin toxicity can take weeks to go away, but they typically resolve themselves as long as the dogs makes it through the rough “overdose” period.
Over the last few days, she has gotten better – at least as far as the ivermectin toxicity symptoms are concerned; she’s still ridiculously itchy – her eyes seem to be returning to normal, her wobbliness is pretty much gone and I haven’t seen her leaning nose first into the wall at all. Last night, she seemed fine all day but then around 8 pm she fell into a deep sleep and had similar symptoms as far as not responding very much to being called, moved, poked, etc. As I write this, she’s sleeping again, but opens her eyes about half-way when I call to her.
So, my questions to you are whether or not any of you have had any experience with being given instructions to give your dog / cat a potentially fatal amount of a medication? How did you handle it with the vet who made the error? Does it seem reasonable to ask them to refund the $80 I paid them for the visit as well as the $550 we had to pay the emergency vet and any associated future costs?
Separately, anyone have any ideas as to what might be causing her itchiness? At this point, with being able to rule out scabies, fleas, and pretty much any other bug with the amount of ivermectin she’s had and the fact that none of the rest of us are itchy, I’m thinking it might be allergies, but then wonder why the Benadryl wouldn’t be helping?
We have a follow-up appointment with our primary vet tomorrow, at the same clinic where we received the bad instructions. I did inform them of the issue and what caused and provided specific numbers / dosages. The poor receptionist sounded as though she wasn’t really sure how to handle it. I was very kind to her, and will be to the medical director when I see him tomorrow, but ultimately want to be sure this never happens to anyone else, and would like to recover the added expense this has caused. We are already on a tight budget and with Sebastian’s recent visits, our budget is stretched even tighter than usual.
Advice or thoughts on any of the issues would be appreciated.
<<Geez, what a long post!>>
Recent Comments